姓 名:范仲雄
职称/职务:副教授
专 业:高分子化学与物理
研究方向:药物传输体系、分子影像探针、
生物医用高分子
联系方式:
邮 箱:fanzhongxiong@xju.edu.cn
办 公 室:beat365官方登录最新网址博达校区beat365官方登录最新网址423
个人经历。。。。 。。。。。。。。。。。。。。。。。。。。。。。。
学习经历:
2018年09月-2022年06月:厦门大学,高分子化学与物理专业,博士;
2014年09月-2017年06月:昌吉学院,材料工程领域专业,硕士(期间:2015年09-2017年03月在厦门大学生物医学工程研究中心交流学习。)
2009年09-2013年06月:天水师范学院,机械设计制造及其自动化专业,学士。
工作经历:
2023年01月-至今:beat365官方登录最新网址,beat365官方登录最新网址,副教授;
2022年06月-2022年12月:beat365官方登录最新网址,beat365官方登录最新网址,讲师;
2017年7月-2018年7月:厦门大学,生物医学工程研究中心,科研助理工作;
2013年07月-2014年08月:航空工业天水飞机有限责任公司,部装车间,助理工程师。
主讲课程
本科生:暂无
研究生:暂无
主持科研项目
1. 新疆维吾尔自治区青年科学基金,2022D01C698,2022/12-2025/12, 7万元,主持人。
2. 福建省自然科学基金项目,双载药同时域缓释型纳米药物的构筑及其协同改善精神分裂症认知功能的研究(2021D028),2021年01月-2024年12月,合作单位主持人。
奖励情况:
2022年获得厦门大学优秀毕业生荣誉称号;
2022年获得厦门大学本栋奖学金(厦门大学校级最高奖学金);
2022年获得厦门大学校级“优秀三好学生”荣誉称号;
2021年获得厦门大学校级“优秀三好学生”荣誉称号;
2021年获得厦门大学材料学院优秀共产党员荣誉称号;
2021年获得厦门大学材料学院2021年度“学习强国”平台“学习之星”;
2020年获得厦门大学校级“三好学生”荣誉称号;
2019年获得厦门大学中国航天科技集团公司CASC公益奖学金;
2018年获得昌吉学院优秀毕业生代表荣誉称号;
2016年获得硕士研究生国家奖学金;
2015年获得新疆维吾尔自治区学位委员会优秀论文奖;
2019年获得厦门大学中国航天科技集团公司CASC公益奖学金;
2011年获得天水师范学院校级“三好学生”荣誉称号。
社会工作
ACS Appl. Mater. Interfaces、Biomater. Sci.、Colloids Surf. B.、J. Mater. Chem. B.、New J. Chem.、Int. J. Pharm.、Drug Delivery等材料、化学、药学领域国际一流期刊审稿人。
代表性研究成果
已发表SCI论文51篇,其中以第一作者、通讯作者、共同第一作者先后发表SCI论文24篇(含JCR 1区论文18篇,2篇影响因子15以上的论文,8篇影响因子10以上的论文,1篇封面论文,1篇Hot Papers论文,H-index 15),授权发明专利2项。已发表主要学术论文如下:
1. Fan, Z.‡; Ren, T.‡; Wang, Y.‡; Jin. H.; Shi. D.; Tan. X.; Ge. D.; Hou. Z., Jin. X.; Yang. L. Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβ clearance. Biomaterials., 2022, 283: 121452.(JCR 1区. IF: 15.304.)
2. Fan, Z.; Jiang, B.; Zhu, Q.; Xiang, S.; Tu, L.; Yang, Y.; Zhao, Q.; Huang, D.; Han, J.; Su, G.; Ge, D.; Hou, Z. Tumor-specific endogenous FeII-activated, MRI-guided self-targeting gadolinium-coordinated theranostic nanoplatforms for amplification of ROS and enhanced chemodynamic chemotherapy. ACS Appl. Mater. Interfaces., 2020, 12(13), 14884-14904.(JCR 1区. IF: 10.383.)
3. Fan, Z.; Shi, D.; Zuo, W.; Feng. J.; Ge. D.; Su. G.;* Yang. L.;* Hou. Z.* Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic imaging-Monitored Chemo-Antiangiogentic Therapy. ACS Appl. Mater. Interfaces., 2022, 14 (4), 5033–5052.(JCR 1区. IF: 10.383.)
4. Fan, Z.; Wang, Y.; Xiang, S.; Zuo, W.; Huang, D.; Jiang, B.; Sun, H.; Yin, W.;* Xie, L.;* Hou, Z.* Dual-self-recognizing, stimulus-responsive and carrier-free methotrexate–mannose conjugate nanoparticles with highly synergistic chemotherapeutic effects. J. Mater. Chem. B., 2020, 8, (9), 1922-1934.(JCR 1区. IF: 7.571.)
5. Fan, Z.; Jiang, B.; Shi, D.; Yang, L.; Hou, Z., Selective antitumor activity of drug-free TPGS nanomicelles with ROS-induced mitochondrial cell death. Int. J. Pharm., 2021, 594, 120184.(JCR 1区. IF: 6.510.)
6. Fan, Z.‡; Liu, G.‡; Li, Y.; Ma, J.; Lin, J.; Guo, F.; Hou, Z.; Xie, L., Self-assembly of the active lactone form of a camptothecin-phospholipid complex for sustained nuclear drug delivery. RSC Adv., 2016, 6 (86), 82949-82960.(JCR 2区. IF: 4.036.)
7. Zhang, X.; Zhu, X.; He, Y.; Zhang, Y.; Huang, S.; Yi, X.; Li, Y.; Hou, Z.; Fan, Z. Biomimetic Dual-Responsive Bioengineered Nanotheranostics for Intracellular Cascade-Synthesizing Chemo-Drugs and Efficient Oncotherapy. J. Mater. Chem. B., 2023, 11 (1), 119-130.(入选HOT Papers. JCR 1区. 影响因子:7.571.)
8. Fu, X.; Yin, W.; Shi, D.; Yang, Y.; He, S.; Hai, J.; Hou, Z.; Fan, Z.*; Zhang, D.*, Shuttle-Shape Carrier-Free Platinum-Coordinated Nanoreactors with O2 Self-Supply and ROS Augment for Enhanced Phototherapy of Hypoxic Tumor. ACS Appl. Mater. Interfaces., 2021, 13 (28), 32690-32702.(JCR 1区. IF: 10.383.)
9. Shi, D.; Zhuang, J.; Fan, Z.*; Zhao, H.; Zhang, X.; Su, G.; Xie, L.*; Ge, D.*; Hou, Z.*, Self-targeting nanotherapy based on functionalized graphene oxide for synergistic thermochemotherapy. J. Colloid Interface Sci. 2021, 603, 70-84. (入选免费cover, JCR 1区. IF: 9.965.)
10. Guo, F.; Shang, J.; Zhao, H.; Lai, K.; Li, Y.; Fan, Z.*; Hou, Z.*; Su, G.*, Cube-shaped theranostic paclitaxel prodrug nanocrystals with surface functionalization of SPC and MPEG-DSPE for imaging and chemotherapy. Colloids Surf. B., 2017, 160, 649-660. (JCR 2区. IF: 5.999.)
10. Zhu, Q.; Fan, Z.‡; Zuo, W.; Chen, Y.; Hou, Z.; Zhu, X., Self-Distinguishing and Stimulus-Responsive Carrier-Free Theranostic Nanoagents for Imaging-Guided Chemo-Photothermal Therapy in Small-Cell Lung Cancer. ACS Appl. Mater. Interfaces., 2020, 12 (46), 51314-51328.(JCR 1区. IF: 10.383.)
11. Yin, W.‡; Fu, X.‡; Chang, W.; Han, L.; Meng, J.; Cao, A.; Meng, J.; Ren, X.; Fan, Z.*; Zhou, S.*, Anti-Ovarian Cancer Mechanism of Esculetin: Inducing G0/G1 Arrest and Apoptosis via JAK2/STAT3 Signaling Pathway, J. Pharm. Pharmacol., 2022, 10.1093/jpp/rgac083, In Press.(JCR 2区. 影响因子:4.810.)
12. Zhu, Q.; Fan, Z.‡; Zuo, W.; Chen, Y.; Hou, Z.; Zhu, X., Self-Distinguishing and Stimulus-Responsive Carrier-Free Theranostic Nanoagents for Imaging-Guided Chemo-Photothermal Therapy in Small-Cell Lung Cancer. ACS Appl. Mater. Interfaces., 2020, 12 (46), 51314-51328.(JCR 1区. 影响因子:10.383.)
13. Xiang, S.‡; Fan, Z.‡; Ye, Z.; Zhu, T.; Shi, D.; Ye, S.; Hou, Z. Endogenous Fe 2+ -activated ROS nanoamplifier for esterase-responsive and photoacoustic imaging-monitored therapeutic improvement. Nano Res., 2021,https://doi.org/10.1007/s12274-021-3574-x.(JCR 1区. IF: 10.269.)
14. Luo, F.‡; Fan, Z.‡; # Yin, W.; Yang, L.; Li, T.; Zhong, L.; Li, Y.; Wang, S.; Yan, J.; Hou, Z.;* Zhang, Q.* pH-responsive stearic acid-O-carboxymethyl chitosan assemblies as carriers delivering small molecular drug for chemotherapy. Mater. Sci. Eng. C., 2019, 105, 110107.(JCR 1区. IF: 7.328.)
15. Sun, H.‡; Fan, Z.‡; Xiang, S.; Zuo, W.; Yang, Y.; Huang, D.; Su, G.; Fu, X.; Zhao, Q.; Hou, Z. Novel, Self-distinguished, dual stimulus-responsive therapeutic nanoplatform for intracellular on-demand drug release. Mol. Pharm., 2020, 17(7) (2020) 2435-2450(JCR 2区. IF: 5.364.)
16. Xie, J.‡; Fan, Z.‡; Yang, L.‡; Zhang, Y.; Fei, Y.; Su, G.; Xie, L.; Hou, Z., Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy. Int. J. Nanomedicine., 2018, 13, 1381-1398.(JCR 2区. IF: 7.033.)
17. Guo, F.‡; Fan, Z.‡; Yang, J.; Li, Y.; Wang, Y.; Zhao, H.; Xie, L.; Hou, Z., A Comparative Evaluation of Hydroxycamptothecin Drug Nanorods With and Without Methotrexate Prodrug Functionalization for Drug Delivery. Nanoscale Res. Lett., 2016, 11 (1), 384. (JCR 2区. IF: 5.418.)
18. Yang, Y.; Fan, Z.‡; Zheng, K.; Shi, D.; Su, G.; Ge, D.; Zhao, Q.; Fu, X.; Hou, Z., A novel self-targeting theranostic nanoplatform for photoacoustic imaging-monitored and enhanced chemo-sonodynamic therapy. J. Mater. Chem. B., 2021, 9 (27), 5547-5559 (JCR 2区. IF: 7.571.)
19. Xiang, S.‡; Fan, Z.‡; Ye, Z.; Zhu, T.; Shi, D.; Ye, S.; Hou, Z. Endogenous Fe 2+ -activated ROS nanoamplifier for esterase-responsive and photoacoustic imaging-monitored therapeutic improvement. Nano Res., 2021, 15 (2), 907.(JCR 1区. 影响因子:10.269.)
20. Luo, F.‡; Fan, Z.‡; Yin, W.; Yang, L.; Li, T.; Zhong, L.; Li, Y.; Wang, S.; Yan, J.; Hou, Z.;* Zhang, Q.* pH-responsive stearic acid-O-carboxymethyl chitosan assemblies as carriers delivering small molecular drug for chemotherapy. Mater. Sci. Eng. C., 2019, 105, 110107.(JCR 1区. 影响因子:7.328.)
21. Sun, H.‡; Fan, Z.‡; Xiang, S.; Zuo, W.; Yang, Y.; Huang, D.; Su, G.; Fu, X.; Zhao, Q.; Hou, Z. Novel, Self-distinguished, dual stimulus-responsive therapeutic nanoplatform for intracellular on-demand drug release. Mol. Pharm., 2020, 17(7) (2020) 2435-2450(JCR 2区. 影响因子:5.364.)
22.Xie, J.‡; Fan, Z.‡; Yang, L.‡; Zhang, Y.; Fei, Y.; Su, G.; Xie, L.; Hou, Z., Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy. Int. J. Nanomedicine., 2018, 13, 1381-1398.(JCR 2区. 影响因子:7.033.)
23.Guo, F.‡; Fan, Z.‡; Yang, J.; Li, Y.; Wang, Y.; Zhao, H.; Xie, L.; Hou, Z., A Comparative Evaluation of Hydroxycamptothecin Drug Nanorods With and Without Methotrexate Prodrug Functionalization for Drug Delivery. Nanoscale Res. Lett., 2016, 11 (1), 384. (JCR 2区. 影响因子:5.418.)
24. Yang, Y.; Fan, Z.‡; Zheng, K.; Shi, D.; Su, G.; Ge, D.; Zhao, Q.; Fu, X.; Hou, Z., A novel self-targeting theranostic nanoplatform for photoacoustic imaging-monitored and enhanced chemo-sonodynamic therapy. J. Mater. Chem. B., 2021, 9 (27), 5547-5559 (JCR 2区. 影响因子:7.571.)
已授权专利:
1. 一种甲氨蝶呤金属配位聚合物及其制备方法和应用,专利号:201910970581.4;
2. 一种多西紫杉醇复合缓释剂及其制备方法,专利号:ZL201711461126.9;